New Diagnosis

Most days in clinic I see patients who are on anti-retroviral medications (ARVs) and are doing excellently. Today for some reason was different. Amidst the routine check-ups and failing teenagers I saw three children who were newly diagnosed. Luckily the number of newly diagnosed children is decreasing all the time in Botswana, so I can often go for a whole week without seeing one. Anyway I thought I would share their stories (I've changed their names).

Mpho is a 12 yr old boy who looked to be about 8. He came to clinic with his older sister. He has been sick on and off for many years now, but never sick enough to get admitted to the hospital. Recently he has had persistent diarrhea (often a sign of HIV infection and something that qualifies him to start on ARVs without even waiting for his CD4 count). His mother has also recently become sick and so his older sisters decided that both he and his mother should be tested. They both tested positive last week. His mother will get started on medications at the local clinic near where they live, but his sister wanted him to be seen at the children's center, so she brought him in. He was quite shy and did not really know why he was there. When I began to tell him about the bad guy in his body that was attacking his soldiers he said he knew that they bad guy was HIV. I asked what he knew about HIV and he said "there is no cure." "That is true, but there are very powerful treatments and with those medications you can live a long and healthy life and be anything you want to be!" He smiled a bit. We sent his baseline blood work, started him on prophylaxis against opportunistic infections, and had long discussion about the importance of adherence and who will help him with his medications. He will return next week to start ARVs.

Nametso is a 7 yr old who came with her mother and her baby sister. She is severely wasted with almost no fat on her body. Her mother is on ARVs already, but for some reason no one ever thought to test Nametso until today. For the last few weeks she has been coughing (occasionally blood tinged), has had fever on and off, and has night sweats (all signs of likely TB infection). Today her mother brought her to be tested and our rapid tests confirmed our suspicions that she is in fact positive. Luckily her baby sister is negative (she was born while the mother was on treatment). Cases like hers really make you realize the importance of asking about all family members and if they know their status. I try always to ask about siblings, parents, etc of the patients I am seeing and we stress the importance of this in the trainings we do, but it it is easy to forget in the course of a busy clinic day. Before we can start her on ARVs, we need to figure out if she has TB. She had signs of pneumonia on examination and I would have liked to get a chest x-ray, but the machine at the hospital has been broken for the last 2 weeks. So I treated her for bacterial pneumonia and arranged for her to get a sputum induction tomorrow (since children are often unable to cough up mucus we have a procedure to help them do that). Unless she gets dramatically better on the standard antibiotics, we will likely empirically start her on TB treatment since it is a hard diagnosis to make in children. And then she too will be started on ARVs.

Then there was Precious. She is 8 months old and was born to an HIV positive mother who actually got the Prevention of Mother to Child Transmission package. However even with the current prevention measures in Botswana, there is still a 4% chance of transmission (<1% in developed countries where women are started on full ARV therapy, given C-sections, and formula feed their babies). She seems to be one of the unlucky 4%. She came today with severe oral thrush. The thrush is so bad that she has not been eating or drinking well and was moderately dehydrated. For the last 4 months she has not gained any weight. She looked severely wasted, dehydrated, and pale (likely also has anemia). One look at her and I knew she had to be admitted. She was tested for HIV back in March (as per the guidelines babies born to HIV positive mothers should be tested around 2 months of age), but the results were never returned. No one told her mother to bring her back for repeat testing (despite the fact that she has not gained weight in 4 months which is often a sign of HIV infection in children) and it wasn't until she got sick that she was brought for repeat testing. With babies we have to do PCR testing which takes at least 2 weeks to get results, but looking at the baby I am pretty sure she will be positive. I walked her over to the pediatric medical ward and discussed the case with the medical officer. He placed an IV, drew blood, and admitted her to begin to rehydrate and stabilize her. We will find out her status for sure in 2 weeks and she will be started on treatment then (assuming it is in fact positive).

Another interesting case of today was Thato. He is 15 and came to clinic with his mother. They were both diagnosed in 2004 and neither has been started on treatment yet. They are both clinically doing well (some patients are able to ward off HIV for a long time before becoming sick). We have been monitoring his CD4 count and it has been steadily dropping over the last year (a sign that he needs to start ARVs soon). However, he and his mother are not ready to start. His mother has found some molasses which is supposed to boost the immune system and they have both started to take that. They are both pretty knowledgeable about HIV and understand that molasses is not a cure for HIV and that the only treatment for HIV is ARVs. His father is actually already on ARVs and doing really well. However, they feel that before starting a life-long therapy all other options should be tried and she wants to see if the molasses will work to boost the immune system and prolong the period of time before which medications have to be started. When I pointed out that the CD4 count was dropping despite the molasses she told me that was because she had not been able to afford the molasses for all of the last year, but that over the last month they were consistently taking it. We agreed to repeat the CD4 in a few weeks and if it is less than 250 (the cutoff in Botswana, though the World Health Organization now recommends 350 and in developed countries it is recommended that patients start way sooner,) he will start ARVs and if it remains high we will continue to wait.

It was a rough day, but luckily they aren't all like this!